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The EMPA-KIDNEY trial enrolled a larger proportion of participants without diabetes mellitus and included individuals with lower mean eGFR (37.3 mL/min/1.73 m) and median UACR (329 mg/g) compared to DAPA-CKD

Orexin is definitely another molecule that is all the rage right now because were seeing the development of orexin agonists and how they may be potentially meaningful in the treatment of narcolepsy

In response to those reports, the European Medicines Agency conducted a review of all available data and concluded that there was no evidence of increased risk of suicidality in people using GLP-1 drugs

However, non-fatal myocardial infarction showed a nonsignificant 9% decrease (HR = 0.91, Fig