glp 1 anxiety People with pre-existing depression or were less likely to have mental health worsening while taking a GLP-1 medication, observational Swedish data suggested. https://www.medpagetoday.com/psychiatry/generalpsychiatry/120515 GLP-1 Medications, Anxiety and Depression:

GLP-1 is a target for treatment of diabetes because of the primary peripheral functions of inducing insulin secretion from pancreatic cells, gut emptying and inhibiting glucagon secretion which results in lower blood glucose levels ( GLP-1 can also be produced by neurons in central nervous system (CNS) ( Pathogenesis of AD Amyloid plaque Amyloid beta (A) is a peptide with a molecular weight of 4 KDa and a length of 40-42 amino acids ( 2+ channels and AMPA (-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, to which the neurotransmitter glutamate binds, so A is the most neurotoxic form ( Neurofibrillary tangles Tau is a microtubule-associated protein and mainly found in the axonal compartment ( Synaptic dysfunction and neurotransmitter imbalance It has been well established that cholinergic transmission is essential for memory, learning, attention, and other higher brain functions, so cholinergic deficits play a key role in the neuropathology of AD ( Neuroinflammation Neuroinflammation, microglia activation in response to amyloid deposition, plays a central role in the pathogenesis of AD ( Insulin resistance For the past few years, AD has also been considered as type 3 diabetes because of insulin resistance (IR) and dysregulation of insulin signaling in the brain ( is mainly transported across the BBB

My pasta theme continues) down to the consumer

A limited number of preclinical studies suggest that berberine may modestly increase endogenous GLP-1 secretion from intestinal L-cells, potentially through effects on gut microbiota or direct stimulation of enteroendocrine cells

They can have steep costs for the monthly dosages and because they are relatively new medications, insurance companies may not approve funding for them