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Mitochondrial to nuclear DNA ratios were measured with quantitative real-time PCR (CFX96, Bio-Rad) with mitochondrial cytochrome c oxidase ( mt-Co1 ) and mitochondrial NADH dehydrogenase 1 ( mt-Nd1 ) and nuclear DNA hexokinase 2 ( Hk2 ) and beta-2 microglobulin ( B2m ) primers (Table 1)

Some patients can reduce insulin significantly, but others remain insulin-dependent and use both medications long-term for optimal control

Clinical trials revealed common side effects such as mild gastrointestinal issues, including nausea and diarrhea

Long-acting release microspheres containing novel GLP-1 analog as an antidiabetic system
