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Inhibition of SGLT2 reduces sodium reabsorption in the proximal tubule and enhances Na + delivery to the macula densa, promoting finally the TGF activation with consequent afferent arteriole vasoconstriction and reduction of the single-nephron-glomerular-filtration-rate ( Figure 1 )

5052 There is also accumulating pre-clinical evidence that GLP-1 and GLP-1RAs may modulate several dysregulated inflammatory pathways and immune cell lineages relevant to IBD, although some findings derive from studies in non-intestinal epithelial or immune cell lineages

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