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[10]org.uk at the time of reading, as appraisals are subject to update) NICE guideline CG189 obesity: identification, assessment and management (verify current identifier and version at nice

Long-term semaglutide safety has been documented in clinical trials spanning up to 2 years, with the most common side effects being mild gastrointestinal symptoms that often improve over time

Semaglutide patients often have better skin elasticity than bariatric surgery patients due to gradual weight loss

Compare this to just 2.4% weight loss with placebo. Even more impressive, 86% of people taking semaglutide achieved clinically meaningful weight loss of 5% or more