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DPP-4 can also have signaling functions via interactions with the extracellular matrix (90), and it was therefore speculated that the DPP-4 inhibitor might have improved insulin sensitivity by interfering with this process in some way rather than by blocking the enzymatic activity per se (79, 89)

CDSCO / Business Standard, March 2026 Phase III Trial Requirement DCGI requires Indian manufacturers to submit Phase III clinical trial data from Indian patients before approval not just bioequivalence data used for standard generics

GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of highfat diet

Liraglutide and semaglutide have beneficial effects on non-alcoholic steatohepatitis