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Conclusions Across preclinical and translational studies, GLP-1RAs have emerged as promising candidates for NDD therapy, consistently modulating convergent mechanisms of pathology: IR, mitochondrial dysfunction, oxidative stress, proteostasis failure, synaptic loss, and neuroinflammation

Study Design We designed this retrospective cohort study to emulate a target trial of GLP-1 RA use compared to an active comparator treatment with dipeptidyl peptidase 4 inhibitors (DPP-4is) for prevention of cirrhosis and related complications in patients with MASLD and diabetes

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