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Accumulation of misfolded proteins in the ER triggers the unfolded protein response (UPR), in which C/EBP homologous protein (CHOP) is activated, subsequently activating the caspase family and inducing chondrocyte death 12

As estrogen declines, body-fat distribution shifts from hips and thighs, where fat is relatively protective, to the abdomen, where it becomes visceral fat , the inflammatory type that wraps around internal organs and drives insulin resistance

(Although some studies say this side effect impacts as many as 11% 13% of people taking Wegovy.) In most cases, sulfur burps arent anything to worry about

doi: 10.2337/dc19-0749 58 O'NeilPMBirkenfeldALMcGowanBMosenzonOPedersenSDWhartonSet al