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The recent NEJM findings suggest GLP-1 pills can provide health improvements that are directly in line with what weve seen in the other injectable GLP-1 receptor agonists, says Matthew Cavender, a study co-author and a cardiologist at the University of North Carolina School of Medicine

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Dehydration risk is highest

Chronic high-carbohydrate diets, gut dysbiosis, inflammation, aging, and metabolic dysfunction can all impair L-cell function and reduce GLP-1 secretion