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Under hyperglycemia, lipids, proteins, and nuclear acids can form advanced glycation end products, interact with the corresponding receptor and finally trigger the activation of inflammation, oxidative stress, and mitochondrial dysfunction, which ultimately induces neuronal injury (4346)

Evidence from randomized controlled trials suggests that OA-related knee pain and function improve with semaglutide but not with liraglutide treatment, and observational studies suggest that GLP-1RA use reduces the risk of surgery for knee OA

What to eat instead: Lean proteins: Chicken breast, turkey, fish, tofu, egg whites, and low-fat dairy, which can make digestion easier

Using both medications at the same time may increase the likelihood of side effects without providing additional benefit