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Not directly, but weight loss, whether from GLP-1 medications including Wegovy, Zepbound, and their compounded forms (such as compounded semaglutide or compounded tirzepatide) or otherwise, particularly when rapid, can lead to muscle breakdown if youre not supporting your body with enough protein, amino acids, and resistance exercise

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If full discontinuation proves unsuccessful after 8 weeks, PlexusDx offers alternative compounds (Tirzepatide, GLP-Squared dual-mechanism therapy) that may provide superior appetite control with lower doses or different mechanisms

When to Talk to Your Doctor If you notice palpitations while taking semaglutide, do not panic