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To further understand the relationship between MOTS-c and -cell senescence, glutamine was treated in either empty or MOTS-c-overexpressed Min6 cells cultured in glutamine-depleted media

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GLP-1 Receptor Signalling Augments Glucose-Mediated Insulin Release The Relationship of GLP-1 and Glucose In addition to triggering insulin secretion directly through the above-described series of events, ingested glucose also stimulates the transcription and release of the insulin secretagogue, GLP-1 (figure 5) [65]