glp 1 and gip agonist The dual glucose-dependent insulinotropic polypeptide (GIP) glucagon-like peptide-1 (GLP-1) receptor tirzepatide: a novel cardiometabolic therapeutic prospect | Cardiovascular Diabetology Bridging the gap between GLP1-receptor

doi: 10.1001/jama.2016.10260 [DOI] [PMC free article] [PubMed] [Google Scholar] 63

In addition to its effects on insulin, GIP plays a crucial role in fat accumulation by promoting the activity of adipocyte-expressed lipoprotein lipase and promoting bone formation by preventing osteoclast apoptosis, as evidenced by the thinner bone trabeculae seen in mice lacking GIP receptors [2022]

Medullary thyroid cancer: Rare thyroid cancer linked to GLP-1 use in animal studies

In contrast to the case reports on altered renal function seen with exenatide, a pooled analysis of 5,594 participants from 19 randomized, controlled clinical trials of exenatide twice-daily (5 g and 10 g) showed that renal impairment-related adverse events, including acute renal failure, were rare (1.6 per 100 person-years for both groups)