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Patients with a history of pancreatitis should not use semaglutide without careful medical review

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The semaglutide 0.5 mg maintenance dose was reached after 4 weeks of semaglutide 0.25 mg onceweekly, and the semaglutide 1.0 mg maintenance dose was reached after 4 weeks of semaglutide 0.25 mg onceweekly, followed by 4 weeks of semaglutide 0.5 mg onceweekly

The overall mechanistic conclusion is well-supported but should be understood as consistent with established biology rather than definitively isolated in retatrutide-specific cardiac experiments