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1921 All outcomes and patient details required for this analysis were routinely collected during the studies

However, both medications have similar side effect profiles, with tirzepatide potentially causing slightly more gastrointestinal symptoms

Although these studies were greatly informative in demonstrating among other things that direct microinjection of GLP1 into the brain (either via administration into the ventricles or hypothalamic as well as extrahypothalamic nucleidiscussed below) may result in decreased food intake/weight gain and improved blood glucose control, it may be difficult to determine the sites of action in intact animals