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demonstrated that GLP-1 agonist administration could lead to an increase in neurogenesis in the hippocampus dentate gyrus region, and demonstrated an improvement in mood and cognitive function through the swim test in adult rodents (Isacson et al., 2011)

Decreased quality of life: Symptoms can make it hard to work and keep up with other responsibilities

DPP-4 inhibitors can on the other hand also be combined with an oral therapy with a SGLT-2 inhibitor (in dual combination when metformin is contraindicated or not tolerated or in triple therapy with metformin)
