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doi: 10.1080/19490976.2023.2274124

Flint, A., Raben, A., Rehfeld, J

The other reason to stack is to cover weaknesses in a single-compound protocol

If using a pen with replaceable needles, attach a new needle according to the manufacturer's instructions, remove both the outer and inner needle caps, and perform a flow check/priming if required by your specific device
