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Additionally, deficiencies in insulin availability are known to contribute to neurodegenerative conditions, but GLP-1s amplify insulin signaling in brain cells, increasing insulin sensitivity in the neurons

35 Furthermore, the RCT LIGHT-ON (NCT02147925) compared the effect of liraglutide, sitagliptin and insulin glargine, when added to metformin in diabetic patients, exhibiting statistically significant results, in favor of liraglutide and sitagliptin, regarding body weight, visceral adipose tissue and liver fat content reduction

Specifically, the decreases in white adipose tissue were accompanied by increases in liver and small intestinal weight by the same magnitude 6

The importance of K10 P lipidation receives the support of our structure-activity relationship study where peptide 20 without K10 P lipidation reduced the receptor-mediated cAMP accumulation by 1,288-fold and 759-fold for GIPR and GCGR in the presence of 0.1% bovine serum albumin (BSA), respectively, but inappreciably influenced that of GLP-1R (Fig