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This "dead space" is unavoidable with standard syringes but can be reduced by using low-dead-space syringes designed to minimize trapped volume

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Dose day is always the hardest

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However, their role has expanded significantly in recent years

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Unadjusted analysis found relatively higher (4 and 5.4% additional) weight loss, HbA1c (0.4% additional) reduction, and fewer gastrointestinal side effects with tirzepatide 10 and 15 mg, respectively, than with semaglutide 2.4 mg [25]

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