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Alfaris said gastrointestinal adverse events were more common with orforglipron than placebo and were consistent with those seen in other incretin-based drugs

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Fiorentino TV, Casiraghi F, Davalli AM, et al (2019) Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas

Cardiovascular outcomes, long-term efficacy and safety In people with T2D and established cardiovascular disease, the international guidelines for T2D recommend the use of GLP-1 RA or sodium glucose co-transporters 2 inhibitors (SGLT-2i) as first-line treatment (independent of HbA1c), based on multiple trials demonstrating their cardio-renal benefits [109]

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