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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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Having pre-made meals eliminates this trigger entirely

Hypothyroidism slows metabolism and makes weight loss harder, but GLP-1 receptor agonists like semaglutide can still be effective when thyroid hormone is optimized
