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The effect of GLP-1RA on the eGFR-related endpoint worsening kidney function was neutral in the main analysis (HR 0.86, 95% CI 0.721.02), while a statistically significant benefit was detected in the sensitivity analysis excluding ELIXA (HR 0.82, 95% CI 0.690.98) [11]

Retatrutides triple agonist activity, targeting GLP-1, GIP, and glucagon receptors, enhances both weight loss and metabolic improvements beyond what is typically observed with GLP-1-only therapy

Studies using dual-energy x-ray absorptiometry and metabolic chambers show that semaglutide users shift toward lower visceral fat stores, which independently improves renal uric acid handling

Because metabolic dysfunction is not just about weight