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Importantly, unlike -adrenergic stimulationinduced increases in myocardial cAMP, which enhance contractility, GLP-1 showed negative inotropic effects in rodent cardiac myocytes, implicating a compartmentalized mechanism of cAMP production away from the contractile apparatus (53)

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ICC generate slow waves that control smooth muscle contractility, are involved in aspects of neurotransmission, set the smooth muscle membrane potential gradient and are involved in mechanotransduction as shown in Fig