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doi: 10.1681/ASN.2006010029 26 CuginiPMuranoGLuciaPLetiziaCScavoDHalbergFet al
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Adipose tissue in obese individuals secretes adipokines (e.g., leptin, lipocalin, resistin) and inflammatory factors (e.g., TNF-, IL-1, IL-6), impacting KOA progression ( The existing studies suggest that GLP-1 RAs protect against KOA through anti-inflammatory, anti-apoptotic, autophagy regulation, macrophage polarization mechanisms, etc
To substantiate the weight-lowering efficacy in another rodent species, Sprague-Dawley rats fed a high-fat high-sugar diet for 4 weeks were treated with once-daily s.c
