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For each comparison of 2G oral semaglutide versus 1G oral semaglutide, two one-sided hypotheses were tested for AUC 024h,SS and C max, 024h,SS values at each dose level: 1: H 0 : 1.25 against H a : 0.80 (where = the geometric mean under treatment with 2G oral semaglutide, divided by the geometric mean under treatment with 1G oral semaglutide)

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Gan & Lee Pharmaceuticals reported on June 30, 2026 in Annals of Internal Medicine that its investigational GLP-1 receptor agonist bofanglutide, dosed once every two weeks, lowered HbA1c at least as much as weekly semaglutide in a 272-patient phase 2b trial in adults with type 2 diabetes