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Endocrinology 148 , 19541962 (2007)

This superior efficacy helped it achieve global sales of ~US$16.4bn in 2024 (Mounjaro ~US$11.5bn and Zepbound ~US$4.9bn), rivalling semaglutide and completely overshadowing the sales of historical GLP-1s, such as exenatide, liraglutide and dulaglutide [FIGURE TWO]

Similarly, in the presence of the GLP-1R antagonist Exendin(939) (Ex9, 100 nM), Ex4 failed to relax cardiac pericytes (capillary diameters remained reduced by 16.22.6% of the initial diameter at n = 22 pericytes in 5 hearts, p = 5.1 10 4 compared to Ex4 only, one-way ANOVA with dks test on final-minute values, Fig

The researchers identified this approach as "corrination," the attachment of corrin ring-containing compounds to GLP-1 agonists