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In wildtype but not GLP-1R KO mice, liraglutide stimulates the secretion of natriuretic peptide (ANP) from the atrial cardiomyocytes and liraglutide fails to affect natriuresis and vasorelaxation in mice deficient for ANP [640]
For others, the safer first step may be labs, lifestyle counseling, treatment of sleep apnea, medication review, or addressing a medical driver of weight gain
Courrges J-P, Vilsbll T, Zdravkovic M, et al
The proteolytic stability to NEP 24.11 could predict mostly the results in mouse plasma
