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Another study determined that combining GLP-1 and estrogen activated estrogen receptors in GLP-1-targeted tissues with unprecedented efficacy in order to improve metabolic syndrome a cluster of conditions including high blood pressure, high cholesterol, and high blood sugar

In contrast, when analyzing stroke outcomes, the effect was more pronounced with GLP-1 RAs, which provided the greatest contribution to the reduction of stroke events

Importantly, these trials exhibited a high degree of heterogeneity in terms of the types of substances studied, patient characteristics, and treatment protocols, which posed significant challenges to drawing definitive conclusions

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