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In addition, because the studies participants had severe hyperglycaemia, metformins glucose-lowering effect may have also been related to changes in peripheral insulin sensitivity, but this was not measured in those studies

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An unpaired t -test was performed if the comparison was for two conditions

In contrast, non-human primates and humans have fewer C cells and less GLP-1R expression, resulting in negligible stimulation of calcitonin release, even at supratherapeutic doses