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However, NHS availability varies by region and local commissioning decisions

Moreover, GLP-1RA anti-catabolic effects can reduce cartilage degradation through the downregulation of TNF-mediated expression of catabolic enzymes, hence preserving essential components of the extracellular matrix such as type II collagen and aggrecan[15]

Informed consent was obtained prior to the study

Healthcare providers typically monitor hemoglobin A1c, fasting blood glucose, lipid panels, kidney function tests (creatinine, eGFR, UACR), and liver function tests to assess treatment efficacy and safety