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Short half-life, pleiotropy, and behavioral or cardiovascular effects were historically interpreted as disqualifying features

[DOI] [PubMed] [Google Scholar] 62.Bjerre Knudsen L., Madsen L.W., Andersen S., et al

Tirzepatide did not demonstrate detectable attenuation of weight reduction-induced decreases in sleeping or 24-h energy expenditure, but there was a reduction in respiratory exchange ratio in the tirzepatide treatment arm compared with that in the placebo arm, consistent with an increase in fat oxidation

This hormone plays a key role in regulating blood sugar by stimulating insulin secretion, suppressing glucagon production, and slowing the rate at which the stomach empties food into the small intestine