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Dehydration decreases blood volume, which can result in orthostatic hypotension (a drop in blood pressure upon standing, typically 20 mm Hg systolic or 10 mm Hg diastolic within 3 minutes) and associated lightheadedness

Researchers continue to study how these heart rate changes relate to the overall cardiovascular benefits associated with tirzepatide
For patients with a history of heart disease, this proven benefit may tip the clinical balance toward semaglutide