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Multivariate analysis showed no difference between placebo and liraglutide arms in HbA1c at 6 months (HbA1c:0.2mmol/mol, 11.3, 11.6, p=0.98) however, at 12 months HbA1c was significantly higher in the liraglutide arm (HbA1c:10.9mmol/mol, 1.1, 20.6, p=0.032)

2SGLT2 inhibitor labeling varies by region and individual agent with regard to indicated level of eGFR for initiation and continued use

In conclusion, GLP-1 RAs are an intriguing multitarget treatment option for people with NDs, and future research should focus on optimizing treatment for clinical trials, evolved agonists that can penetrate the central nervous system (CNS), and combination therapies.