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Strengthening primary healthcare, expanding early screening and ensuring reliable access to essential medicines are some of the most effective ways to change this trajectory
The glucagon receptor activation, which is the unique component missing from both semaglutide and tirzepatide, promotes energy expenditure and modulates hepatic glucose production, leading to increased thermogenesis and lipid mobilization
Acknowledgments We would like to thank the Italian Society for Pediatric Endocrinology and Diabetes (ISPED) for its support to the Genetic Obesity Study Group, which is joined by most of the authors
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