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Muscle is hungry tissue

10.1172/jci.insight.94263 85 StergiouC.LazaridisK.ZouvelouV.TzartosJ.MantegazzaR.AntozziC.et al (2016)

They work by making you feel full longer, slowing digestion, and improving how your body processes insulin, which can lead to significant weight loss

A recent report demonstrates that administration of metformin increased mRNA expression of the receptors GLP-1R and GIPR in mice