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11 Proposed mechanisms include central activation of preproglucagonexpressing neurons in the nucleus tractus solitarius and stimulation of corticotropinreleasing hormoneproducing neurons in the hypothalamus, linking GLP1 signalling to modulation of the HPA axis

PMID: 21454562

The authors emphasize: An immediate reduction in the bolus insulin by 2030% is very important with initiation of semaglutide to minimize the risk of hypoglycemia. --- How does this fit with the broader GLP1RA evidence in T1D

"What I've done, and I've spoken to other doctors in obesity medicine who are doing the exact same thing, is we'll say, 'Okay, instead of taking [an injectable dose] every week, let's try taking it every two weeks.'" She continued, "Alternating one week on, one week off may be something that we start to see in the future become a more common, more official part of the maintenance regimen."