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Discontinuation rate: Only 1-2% stop during this period Psychological state: Highly motivated, visible results drive continued adherence Key achievement: Halfway to goal with strong momentum Weeks 25-36: The Steady State Phase (12mg Maintenance) Starting Weight Week 25: ~182 pounds | Expected Weight Week 36: 174-178 pounds | Net Loss This Period: 4-8 pounds | Total Loss: 42-46 pounds Whats Happening Physiologically Metabolic adaptation intensifies

The fix: Continue the Retatrutide eating protocol through week 48 and beyond

These findings were consistent in patients with and without obesity

Figure 2 suggests a decision algorithm for prescribing GLP-1RA plus SGLT2i combination therapy in patients with T2DM