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In humans, systemic DAergic drugs have been shown to modulate RPEs 12 , increase sensitivity to RPEs 13,14,15 , and influence reversal learning performance 15,16

This approach is often used for older or less fit patients due to its less invasive nature compared to abdominal procedures

This is of potential consequence when drug discontinuation is required or when drugs are prescribed that might interact with fluoxetine and norfluoxetine following the discontinuation of fluoxetine [see Clinical Pharmacology (12.3) and Drug Interactions (7)]