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PD-1 knockout CAR-T therapy Knocking out the PD-1 gene in CAR-T cells can significantly enhance T cell immune activity, thereby improving the clinical efficacy of CAR-T therapy in antitumor treatment (Figure 4D)

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Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK

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