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Experimental or investigational : Medications considered experimental or investigational, lacking clinical evidence

Glucagon, the ligand of GCGR, increases insulin secretion via GCGR and GLP-1R in pancreatic cells, although GLP-1R is the main insulin-promoting receptor

Eating disorders are serious mental health disorders characterized by severe disturbances in eating behaviors and thoughts about food, which can lead to serious health problems and significant medical complications

Consistent with the restoration of lipid catabolic gene expression, GSEA demonstrated significant enrichment of fatty acid metabolism (NES = 1.575, P = 0.0061) and fatty acid degradation pathways (NES = 1.729, P = 0.0020) in the HFD + Ret group compared with the HFD group