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One potential reason leptin has not panned out as a therapy on its own is a phenomenon known as leptin resistance. Thats when the body becomes desensitized to the hormone at higher levels, causing a person to feel hungry and eat more even though they have sufficient body fat

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But it's not universal that they affect your desire for alcohol either

Findings from experiments on mice, published this week in the Journal of Virology , suggest that the drugs may offer benefits to another patient population: people with type 2 diabetes who suffer from pulmonary fibrosis months or years after infection with SARS-CoV-2, the virus that causes COVID-19