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Glucagon is traditionally known for raising blood sugar, but in this specific tri-agonist configuration, sustained glucagon receptor activation drives thermogenesis (energy expenditure) and promotes lipid oxidation in the liver
Conditions like type 2 diabetes, hypertension, and sleep apnea can improve substantially with 10 to 15% weight loss
This finding remained consistent across subgroups stratified by psychiatric history, obesity, sex, and age
