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They do not rebuild the system required for metabolic resilience, a system that sits at the center of GLP-1 microbiome science and is powered primarily by the gut microbiome, SCFAs, inflammation control, circadian timing, and mucosal structure

These medicines may also decrease inflammation and help modulate fat metabolism

The medication works as a GLP-1 receptor agonist, enhancing satiety signals and slowing gastric emptying, leading to sustained weight reduction when combined with lifestyle changes

Semaglutide (Wegovy) a licensed GLP-1 receptor agonist approved by the MHRA for weight management in eligible adults, as assessed in NICE technology appraisal TA875