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Description
The gap narrows somewhat at 48 weeks but remains meaningful
After cooling the solution to room temperature (RT), a separate solution containing 1-dodecylisocyanate (105 mg, 0.5 mmol) and N,N-diisopropylethylamine (Hunigs base, 3 drops) in 5 mL of NMP was prepared and added dropwise to the polymer solution
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The drug or matching placebo were given for 12 months and the primary endpoint, as shown below, was a motor score used by neurologists (Movement Disorder Scale-Unified Parkinsons Disease Rating Scale) MDS-UPDRS Part III)
