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Regarding co-agonist treatment, tirzepatide was recently shown in a post hoc analysis of the SURMOUNT-1 trial to also reduce UACR in overweight/obese people without T2D (88), and similar benefits for kidney function were shown in subjects with heart failure (89)

Subsequent administration of the GLP-1 receptor agonist semaglutide (Sem) to dams in late pregnancy revealed a modest decrease in maternal food intake during initial treatment

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Figure 1 illustrates the diverse physiological effects of GLP-1RAs across major organ systems, including the pancreas, liver, brain, cardiovascular system, kidneys, gastrointestinal tract, and adipose tissue