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Conclusions Semaglutide 2.4 mg was cost-effective compared to D&E alone for patients with obesity (BMI30 kg/m2) and weight related comorbidities in Portugal, over a 40-year time horizon.
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However, the commonly used diet-induced obesity model in C57BL/6J mice is limited by relative resistance to weight gain in females, complicating the study of sex-specific effects
