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Thus, we found that agonists that preserve higher levels of surface and total receptor, either by reduced internalization, increased recycling, or both, allow responsiveness retention during continuous or interrupted stimulation

N Engl J Med 375:311322 Ahrn B, Masmiquel L, Kumar H, Sargin M, Karsbl JD, Jacobsen SH, Chow F (2017) Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial

Based on rodent studies, GLP1 receptor agonists also vary with respect to brain availability and how discrete or extensive brain regions show GLP1 receptor binding after systemic GLP1 receptor agonist administration (Gabery et al., 2020