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Vitamin B6 and folate can help support the production of neurotransmitters important to your mood health, along with healthy brain and nervous system function

(A) Triple immunofluorescence labeling of microglia for IBA-1 (pink), astrocytes for GFAP (red) and neurons and neurofilaments for NF-200 (green) obtained from longitudinal sections centered around the injured core 3 mm at 7 dpi and 28 dpi in Sham, SCI and Ex-treated SCI mice

A parallel line of work frames Alzheimers disease as a state of central insulin resistance, sometimes called type 3 diabetes, in which GLP-1R agonism restores neuronal insulin signalling, improves mitochondrial function, and reduces oxidative stress
This overlap highlights their promise as pharmacological analogues of exercise, and underscores the need for biomarker-driven, disease-specific trials to establish whether GLP-1RAs can deliver durable disease modification across the spectrum of neurodegenerative diseases
