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Biologic therapies have transformed Crohn's disease management and include several FDA-approved options: TNF- inhibitors : Infliximab (Remicade), adalimumab (Humira), and certolizumab pegol (Cimzia) block tumor necrosis factor-alpha, a key pro-inflammatory cytokine

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Statistical analyses included chi-square tests, independent t tests, Kaplan-Meier survival analysis, and calculations of Cohen d for effect sizes

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