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[16] DPP-4 inhibitors (such as sitagliptin), which enhance incretin activity through a different mechanism Insulin therapy, particularly if oral agents and other injectables are unsuitable Traditional agents like metformin, sulphonylureas, or pioglitazone, depending on individual circumstances NICE guideline NG28 recommends individualised treatment approaches based on HbA1c targets, cardiovascular risk, renal function, and patient preferences

The long elimination half-life of 25-68 hours further supports convenient once-daily dosing

This is why it is crucial to preserve muscles while taking semaglutide

Choose appropriate beverages : Water is ideal, but sugar-free squash, herbal teas, and clear broths also contribute to hydration